Include minority groups in trials

Scientists and researchers have long failed at inclusiveness in clinical research trials. African Americans, Native Americans and Hispanic patients in particular are largely underrepresented in research into drugs and other disease treatments. Overall, African Americans make up about 13 percent of the population, but just 5 percent of clinical trials. And Hispanics fare even worse; they make up 18 percent of the population, but just 1 percent of clinical trial research, according to Clinical Research Pathways.

A 2018 ProPublica analysis found this is true even when a particular disease disproportionately affects one of these groups. One out of five people diagnosed with multiple myeloma in the U.S. is Black, and African Americans are more than twice as likely as white Americans to be diagnosed with the blood cancer overall, yet, the U.S. Food and Drug Administration approved a drug to treat it in 2015 after a trial in which just 13 of 722 participants, or 1.8 percent, were Black. Disease can manifest itself in different ways depending on a person’s ethnicity and race. Leaving people out of trials means certain groups risk not getting the best treatment.

Unfortunately, we’re seeing the same playbook once again as scientists rush to develop a vaccine for COVID-19. It’s no surprise drugmakers are far from having the number of people of color they should for a truly representative trial — though we wish it was, especially since the racial disparities that come along with COVID-19 are so jarring. On Sept. 22, the Centers for Disease Control and Prevention said the disease is killing Hispanic, Black and Native American children at a much higher rate than white children. More than 78 percent of children who have died from COVID-19 have been from these three minority populations, groups that make up only 41 percent of the U.S. population. Similar disparities exist for adults as well.

Scientists should have known at the outset to make the extra effort to reach out to communities of color, knowing the history and realizing their obligation to come up with a vaccine that works for a diversity of people. Instead, two drugmakers leading development of a vaccine, Moderna and Pfizer, said late last month they had enrolled more than half the people needed for trials of 30,000 people, but only about a fifth were Black or Hispanic.

We need minority groups in these trials. It is their mothers, aunts, sons and daughters who are more likely to contract the disease and die from it.

* Guest editorial from The Baltimore Sun in Baltimore, Md.


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